全文获取类型
收费全文 | 8481篇 |
免费 | 607篇 |
国内免费 | 123篇 |
专业分类
耳鼻咽喉 | 66篇 |
儿科学 | 222篇 |
妇产科学 | 395篇 |
基础医学 | 968篇 |
口腔科学 | 188篇 |
临床医学 | 1038篇 |
内科学 | 1697篇 |
皮肤病学 | 85篇 |
神经病学 | 714篇 |
特种医学 | 270篇 |
外科学 | 1084篇 |
综合类 | 249篇 |
一般理论 | 4篇 |
预防医学 | 465篇 |
眼科学 | 221篇 |
药学 | 743篇 |
中国医学 | 86篇 |
肿瘤学 | 716篇 |
出版年
2023年 | 43篇 |
2022年 | 31篇 |
2021年 | 167篇 |
2020年 | 115篇 |
2019年 | 189篇 |
2018年 | 215篇 |
2017年 | 180篇 |
2016年 | 180篇 |
2015年 | 252篇 |
2014年 | 291篇 |
2013年 | 394篇 |
2012年 | 565篇 |
2011年 | 645篇 |
2010年 | 419篇 |
2009年 | 366篇 |
2008年 | 528篇 |
2007年 | 525篇 |
2006年 | 532篇 |
2005年 | 478篇 |
2004年 | 413篇 |
2003年 | 338篇 |
2002年 | 298篇 |
2001年 | 271篇 |
2000年 | 229篇 |
1999年 | 195篇 |
1998年 | 70篇 |
1997年 | 63篇 |
1996年 | 57篇 |
1995年 | 49篇 |
1994年 | 40篇 |
1993年 | 40篇 |
1992年 | 112篇 |
1991年 | 117篇 |
1990年 | 96篇 |
1989年 | 72篇 |
1988年 | 72篇 |
1987年 | 73篇 |
1986年 | 47篇 |
1985年 | 41篇 |
1984年 | 33篇 |
1983年 | 35篇 |
1981年 | 24篇 |
1980年 | 18篇 |
1979年 | 27篇 |
1978年 | 33篇 |
1977年 | 18篇 |
1975年 | 18篇 |
1974年 | 26篇 |
1973年 | 17篇 |
1968年 | 18篇 |
排序方式: 共有9211条查询结果,搜索用时 15 毫秒
61.
Jan Dommerholt Li-Wei Chou Todd Hooks Jacob N. Thorp 《Journal of bodywork and movement therapies》2019,23(4):773-784
This quarter's overview of the myofascial pain literature includes quite a few basic research papers in addition to the usual high quantity of dry needling (DN) papers. Of particular interest are a study by Fischer and colleagues studying the role of mitochondrial functions in chronic trigger points (TrPs) (Fischer et al 2018), a study by Li and associates who conducted a quantitative proteomics analysis to identify biomarkers of chronic myofascial pain and therapeutic targets of dry needling in a rat model of TrPs (Li et al 2019), and a sonography study by Mitchell et al. looking into the distances from the skin to the pleura in the context of DN (Mitchell et al 2019). A total of 33 papers are included in this overview article.We welcome Dr. Jacob Thorp to our team of authors. Dr. Thorp is a US-based physical therapist. He is Professor and Founding Director of the Physical Therapy Program at Charleston Southern University in North Charleston, SC. 相似文献
62.
The purpose of this study was to investigate the typical development of postural control in younger (5-6 yrs) and older (7-16 yrs) children (YTD and OTD) during two gait tasks, including level walking and obstacle-crossing, using a dual-task paradigm, and to compare the results of the children's performance with that of healthy young adults (HYA). Our findings revealed that gait control in typical children requires attentional resources to maintain stability. Moreover, dual-task interference was less in HYA compared to YTD and OTD. Gait performance decrements in the dual-task context were greater in YTD compared to OTD, whereas cognitive performance decrements in YTD and OTD were similar. In addition, dual-tasking affected cognitive performance more in YTD when gait task difficulty was increased. Results suggest a developmental trend in attentional resources used to control gait in typical children. Postural control during gait under dual-task conditions was improved when children were more mature, as attentional resources increased with age. 相似文献
63.
Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta 下载免费PDF全文
Cheung YY Kim SY Yiu WH Pan CJ Jun HS Ruef RA Lee EJ Westphal H Mansfield BC Chou JY 《The Journal of clinical investigation》2007,117(3):784-793
Neutropenia and neutrophil dysfunction are common in many diseases, although their etiology is often unclear. Previous views held that there was a single ER enzyme, glucose-6-phosphatase-alpha (G6Pase-alpha), whose activity--limited to the liver, kidney, and intestine--was solely responsible for the final stages of gluconeogenesis and glycogenolysis, in which glucose-6-phosphate (G6P) is hydrolyzed to glucose for release to the blood. Recently, we characterized a second G6Pase activity, that of G6Pase-beta (also known as G6PC), which is also capable of hydrolyzing G6P to glucose but is ubiquitously expressed and not implicated in interprandial blood glucose homeostasis. We now report that the absence of G6Pase-beta led to neutropenia; defects in neutrophil respiratory burst, chemotaxis, and calcium flux; and increased susceptibility to bacterial infection. Consistent with this, G6Pase-beta-deficient (G6pc3-/-) mice with experimental peritonitis exhibited increased expression of the glucose-regulated proteins upregulated during ER stress in their neutrophils and bone marrow, and the G6pc3-/- neutrophils exhibited an enhanced rate of apoptosis. Our results define a molecular pathway to neutropenia and neutrophil dysfunction of previously unknown etiology, providing a potential model for the treatment of these conditions. 相似文献
64.
65.
Cutaneous burn wounds represent a significant public health problem with 500,000 patients per year in the USA seeking medical attention. Immediately after skin burn injury, the volume of the wound burn expands due to a cascade of chemical reactions, including lipid peroxidation chain reactions. Such expansion threatens life and is therefore highly clinically significant. Based on these chemical reactions, the present paper develops for the first time a three-dimensional mathematical model to quantify the propagation of tissue damage within 12 hours post initial burn. We use the model to investigate the effect of supplemental antioxidant vitamin E for intercepting propagation. We show, for example, that if tissue levels of vitamin E tocotrienol are increased, postburn, by five times then this would slow down the lipid peroxide propagation by at least 50%. We chose the alpha-tocotrienol form of vitamin E as it is a potent inhibitor of 12-lipoxygenase, which is known to propagate oxidative lipid damage. Our model is formulated in terms of differential equations, and sensitivity analysis is performed on the parameters to ensure the robustness of the results. 相似文献
66.
This study proposes a cost-effective, energy-saving, and green process that uses π–π interactions to modify graphene oxide (GO), and the conjugate structure of aniline tetramer (AT) to enhance the dispersion of GO. Au/aniline tetramer–graphene oxide (Au/ATGO) composites were synthesized and applied as a catalyst in this study. The adsorption of AT on GO, via π–π interaction, formed ATGO composites. Subsequently, the amine group on ATGO was stably anchored on Au nanoparticles (Au NPs) to form Au/ATGO composites. The Au/ATGO composites were characterized and the electroactive properties determined by Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, and cyclic voltammetry. The Au/ATGO composites showed excellent performance and stability as catalysts when applied for the reduction of nitrophenol to aminophenol within 225 s and the rate constant was 0.02 s−1. The activation energy for the reduction of 4-NP and 2-NP was 48.10 and 68.71 kJ mol−1, respectively. Following a recycling test repeated 20 times, the Au/ATGO composites maintained a conversion rate higher than 94%.The stable and reusable Au/ATGO composites were prepared. Aniline tetramer not only modified GO but also can anchor Au NPs. The Au/ATGO composites as a catalyst exhibit good cycling stability. 相似文献
67.
68.
69.
70.